PIN1 and early-onset autosomal dominant Alzheimer disease: Of interest, the irreversible oxidation of human PIN1 was associated with various pathologies as mild cognitive impairment or Alzheimer’s disease (Butterfield et al., 2006; Sultana et al., 2006) and induces a decrease of reactivity and mislocalization impairing the physiological function of the protein (Chen et al., 2015).