SARS-CoV-2 can infect the cerebral cortical neurons, cells that do not express ACE-2 receptor but contain TLR4 receptor, and activate the pro-inflammatory response, suggesting that the TLR4 is involved in SARS-CoV-2 entry and could be related to the neurological manifestations of COVID-19 (99). The gene discussed is TLR4; the disease is COVID-19.