The upregulated CCL4 could recruit a higher proportion of CD8 + T cells (P = 0.019), NK cells (both resting and activated, P = 0.041 and 0.010, respectively), M1 macrophages (P = 0.044), and activated mast cells (P = 0.041) into inflammatory sites (skin, eyes and even vascular), which likely exacerbates proinflammatory situation, immune cell function and intensify disease activity in BD patients. Here, CD8A is linked to Behcet disease.