Moreover, we noticed that even certain metabolites with no significant changes in their levels (P > 0.05), such as 3-hydroxyphenylacetate and prostaglandin H2, were also significantly correlated with IL-12, MCP-1 and IL-7 among patients with MS (Padj < 0.05) (Figure S5), respectively. This evidence concerns the gene CCL2 and myeloid sarcoma.