We also found that some differential metabolites like trans-cinnamate and sphingosine 1-phosphate was significantly correlated with IL-13, IP-10, IFN-γ, and Eotaxin (Padj < 0.05), respectively, despite the lack of any obvious change in the levels of these chemokines in patients with MS (Figure 6). This evidence concerns the gene IFNG and myeloid sarcoma.