(72) found that treatment with IL-2/IL-2 antibodies complex can significantly increase the number of CD39+ Tregs and CD73+ Tregs in blood, spleen and lymph nodes, which exerted a neuroprotective effect against cerebral ischemia IL-33 is a novel cytokine of the IL-1 family with a protective effect against ischemic brain injury. The gene discussed is IL2; the disease is brain ischemia.