In conclusion, our observations indicate that the inhibition of TNF-α, IL-1β and IL-8 production in RASFs and in serum and synovial tissue from CIA mice attenuates signs and symptoms of RA (Figure 9) and that Antcin K significantly inhibits these proinflammatory cytokines via the FAK/PI3K, AKT and NF-κB signaling cascades. The gene discussed is TNF; the disease is rheumatoid arthritis.