Additionally, some of the purple module hub-high traffic genes, such as MAPK1 (189, 374), CUL2 (210), CMTM6 (162), TXNRD1 (375), RAB1A (376), DICER1 (377), RAB5A (209), HSP90B1 (343), MAGT1 (378), ADAM10 (379, 380), SNX2 (89), OLA1 (381), SPTLC1 (382), SH3GLB1 (383), TIMM10B (384), and CREB1 (385) hub-high traffic TF, which are central for information exchange in this module, are potential targets for development of COVID-19 therapeutic strategies. Here, CUL2 is linked to COVID-19.