Additionally, some of the purple module hub-high traffic genes, such as MAPK1 (189, 374), CUL2 (210), CMTM6 (162), TXNRD1 (375), RAB1A (376), DICER1 (377), RAB5A (209), HSP90B1 (343), MAGT1 (378), ADAM10 (379, 380), SNX2 (89), OLA1 (381), SPTLC1 (382), SH3GLB1 (383), TIMM10B (384), and CREB1 (385) hub-high traffic TF, which are central for information exchange in this module, are potential targets for development of COVID-19 therapeutic strategies. The gene discussed is CREB1; the disease is COVID-19.