Studies have shown that PI3K-Akt signaling pathway is involved in the occurrence of ulcerative colitis and can be activated by intestinal inflammation (74, 75), and its inhibition can down-regulate the expression of nuclear transcription factors-κB (NF-κB) to reduce the expression of proinflammatory cytokines (76, 77). Here, NFKB1 is linked to ulcerative colitis.