A study carried out on Hodgkin lymphoma (HL) and on diffuse large B-cell lymphoma (DLBCL) patients’ samples, described an immune evasion mechanism mediated by CD163+ monocytes/macrophages expressing PD-L1/PD-L2 that promoted NK cell phenotype switching towards an exhausted PD1hiCD3-CD56hiCD16+/- phenotype evaluated in terms of expression of markers of activation. The gene discussed is PDCD1LG2; the disease is diffuse large B-cell lymphoma.