TNFRSF13B and common variable immunodeficiency: In line with previous reports in CVID, more than 29.2% of our positive or possible cases (Figure 2C) were found to carry known deleterious changes in TNFRSF13B (11, 57, 73), although mutations in this gene are currently considered risk alleles rather than disease-causing variants, as they are also found in asymptomatic carriers (11, 82).