Dysregulation of systemic levels of gal-3 have been described in pregnancy complications, particularly the so-called ‘Great Obstetrical Syndromes’ including preeclampsia (42, 93), IUGR (91), preterm birth and premature rupture of membranes (94, 95), and spontaneous pregnancy loss (96), all of which are associated with disorders of deep placentation. The gene discussed is LGALS3; the disease is fetal growth restriction.