RNA sequencing analysis of the transcriptome of brain macrophages revealed high activity of biological processes linked to neurovascular remodeling, such as angiogenesis and NSC proliferation (e.g., GDF15, VEGF, and FGF1), as early as 5 days after stroke and lasting for at least 21 days, and peptidases capable of modulating ECM components (e.g., MMP-14 and ELANE) were also upregulated (84). The gene discussed is VEGFA; the disease is stroke disorder.