Expression of FOXP1 and SIRT1, which can suppress antitumor T cells (108) and promote chemoresistance (109, 110), has been found in CRC infiltrating Tregs (FOXP1), CD8+ and memory resting CD4+ cells, but also in naïve and memory B lymphocytes (both FOXP1 and SIRT1). The gene discussed is CD4; the disease is colorectal carcinoma.