CD274 and colorectal carcinoma: Bioinformatic analyses of gene expression data from CRC samples of TCGA PanCancer collection, revealed that among immune exhaustion-related genes, the expression of those coding for PD-L1, LAG3 and T-bet was associated (Cramér’s V=0.3) with MSI/dMMR tumors, which were diagnosed in 63/594 (10.61%) of CRC patients (Table 5).