While confirming the previously reported observation of high levels of expression of PD-L1, LAG3 and T-bet in the context of MSI tumors (39, 47, 49), our findings reveal that, independently of tumor stage and molecular subtype, high levels of a wide range of inhibitory receptors and exhaustion-related transcription factors, such as EOMES, T-bet, PD-L1, PD-1, LAG3, BTLA, FCRL4, SIGLEC6 and TRAF1 are associated with reduced survival in CRC patients. This evidence concerns the gene SIGLEC6 and neoplasm.