Analysis of RNA-seq data from the TCGA PanCancer cohort and morphological investigations of CRC samples from the validation cohort, reveal that expression of PD-L1, PD-1, LAG3, EOMES, T-bet and TIGIT is associated and co-localizes not only with CD8+ and CD4+CD3+ T cells, but as well as with the expression of PD-L2 and IDO1, it co-occurs with typical markers of cNK cells, which are identified as NKp46+EOMES+T-bet+CD94+, a subset of group 1 ILCs (34). Here, CD4 is linked to colorectal carcinoma.