Intestine:InL, ILI, IW and ISI↑Mucosal permeability ↓Improved the intestinal histological pathological symptoms after infection;Expression of 9 TJ-related genes (zo-1, -2b, oc, jam-a, claudin-b, -c, -f, -3c, -11) ↑, and 2 (claudin-12 and -15a) ↓, and claudin-7a, -7b and -15b –;Expression of 5 AJC-related genes (e-cadherin, α-catenin, β-catenin, nectin, afadin) ↑;Expression of 4 AJC-related genes (rhoa, rock, mlck and nm-ii) ↓;GTP-RhoA protein levels ↓. Here, CLDN12 is linked to infection.