Three (IL-17 signaling pathway, Malaria and Renin-angiotensin system) out of seven ILLN KEGG pathways were enriched with down-regulated genes while the other four (NF-κB signaling pathway, Mineral absorption, Melanoma and Rheumatoid arthritis) were enriched with both up- and down-regulated genes (Supplementary Table S6B). The gene discussed is REN; the disease is rheumatoid arthritis.