However, in Drosophila, the PGRP-SA/GNBP1 complex solely recognizes Gram-positive bacterial and fungal infections, whereas Gram-negative bacteria can be sensed by the alternative receptors PGRP-LC and PGRP-LE and triggers the Imd signaling pathway (6, 27–31). This evidence concerns the gene PGLYRP1 and fungal infectious disease.