P2RX7 and amyotrophic lateral sclerosis: In another pro-inflammatory context, reactive astrocytes derived from Amyotrophic Lateral Sclerosis (ALS) model hSOD1G93A transgenic mice present an increased abundance of several migration-related molecules, including αvβ3 Integrin, syndecan-4 proteoglycan, P2X7 receptor, PANX1, and CX43 (97).