In addition, some evidence suggests a non-channel contribution of PANX1 during migration of rhabdomyosarcoma (102, 103), which has been observed in other channels that can act as signaling proteins such as CX43 (76), or as enzymes and therefore receive the name of ‘chanzymes’, such as TRPM7 (149). Here, PANX1 is linked to rhabdomyosarcoma.