While the effects of TCZ on angiogenesis have yet to be investigated in depth, TCZ has been shown to reduce VEGF serum levels in complete Freund’s adjuvant (CFA)-induced arthritic rats (11), and to reduce the mean vessel density (MVD) in the synovium of RA patients as evaluated by immunohistochemical staining for the endothelial marker CD31 (12). The gene discussed is VEGFA; the disease is rheumatoid arthritis.