The analysis showed the significant genes expressed in other studies are CXCL1, CXCL6, CXCL8, IL33, TIMP1, IL18, IFNGR2, TRIM27, TRIM28, IFI6, XAF1, CXCL5, IFIT1, IL6, IL10, and CSF2, etc. The analysis will help to understand the DEGs in mild and severe COVID-19 patients. This evidence concerns the gene IFI6 and COVID-19.