When applying age related cut offs for CSF-NfL and evaluating the entire AE cohort and the idiopathic/teratoma associated NMDAR- and LGI1-AE combined, an association between elevated CSF-NfL at diagnosis and a poor outcome was found (p=0.0009 and p=0.006) (Figures 2C, D). The gene discussed is NEFL; the disease is teratoma.