IL6 and systemic lupus erythematosus: Accordingly, the special design of this study (e.g. time-series analysis on 112 12 h measurements) allowed us to show in a patient with SLE i) normal or even reduced mean urinary IL-6 concentrations (see Table 1) (17), ii) an 8-lag (96 h) circasemiseptan (about-half-weekly) (28) rhythmic pattern in the urinary IL-6 time series (see Table 2), and iii) clear interdependencies between the 12 h variations in urinary IL-6 concentrations and the 12 h variations in SLE symptoms.