Genetic vaccination has the potential to redirect CD4+ lymphocyte immune response to Candida and Aspergillus toward a Th1 phenotype, for instance by co-expressing with the selected antigen a Th1 polarizing cytokine such as γ-IFN whose beneficial effect in fungal infections has already been demonstrated (Nagai et al., 1995; Sainz et al., 2007; Buddingh et al., 2015). The gene discussed is CD4; the disease is fungal infectious disease.