Over 100 IBD susceptibility genes found in IBD and zebrafish share homologous genes like NOD1, NOD2, e-cadherin, hnf4a, and ttc7a, suggesting it is a suitable animal model (Oehlers et al., 2011; Jostins et al., 2012; Zhao et al., 2018). Here, HNF4A is linked to inflammatory bowel disease.