Information on efficacy and safety of GnRHa plus rhGH is available for the following conditions: 1) growth hormone deficiency (GHD); 2) short stature after being born small for gestational age (SGA); 3) ISS; 4) haploinsufficiency of SHOX, NPR2 or ACAN; 5) CPP; 6) congenital adrenal hyperplasia (CAH); and 7) hypothyroidism. Here, ACAN is linked to congenital adrenal hyperplasia.