Nucleoside diphosphate kinase; NME2 has a major role in the synthesis of nucleoside triphosphates (GTP, CTP and TTP but not ATP). It suppresses Rho activity by interacting with AKAP13/LBC. Rho (GTPases) are indirectly linked to cancer by their interaction with known oncogenes (e.g. Raf and Ras), (43). NME2 also acts as a transcriptional activator of the MYC gene. This evidence concerns the gene RHO and cancer.