PRKAA2 and Hypoglycemia: Previous studies have shown that direct pharmacological activation of AMPK in the ventromedial nucleus of the hypothalamus (VMH), an important hypoglycemia-sensing brain region (9), increases the response to hypoglycemia in healthy (10), recurrently hypoglycemic and diabetic BB rats (11) by increasing hepatic glucose production (HGP) with or without concomitant increases in glucagon and adrenaline levels.