CD4 and myasthenia gravis: However, the Tr1/CD4+ T cell ratio and the Tr1/FoxP3+ Treg cell ratio in MG patients tend to decrease compared with normal controls, but there were also no significant differences in the proportion of Tr1 cells to CD4+ T cells (median values 0.02 vs. 0.10%, p = 0.217) or in the Tr1 cell/FoxP3+ Treg ratio (median values 0.01 vs. 0.02%, p = 0.589) between the MG patients and NCs.