APP and neuroblastoma: Studies on the mechanism of action found that tenuifolin B could inhibit secretion of Aβ in neuroblastoma cells stably transfected with two amyloid precursor protein (APP) constructs: the APP695 cDNA (SH-SY5Y APP695) and the C-terminal 99 amino acid residues of APP plus the signal peptide (SH-SY5Y SPA4CT).