ITPR2 and diabetes mellitus: They also found the interaction between FUNDC1 and IP3R2 is significantly increased in streptozotocin-induced diabetic mice heart, leading to stabilization of IP3R2 and mitochondrial Ca2+ increase and mitochondrial dysfunction (Wu et al., 2019), whereas diabetes mellitus-induced MAMs formation and mitochondrial Ca2+ elevation and mitochondrial fission, and apoptosis are restored when Fundc1 is specifically knockout in mouse heart (Wu et al., 2019).