Previous studies have demonstrated that the NF-κB/NLRP3 inflammasome signaling pathway is activated in DN and accelerates renal damage (Yi et al., 2017; Tian et al., 2021), while Liu et al. (2020) also showed that NF-κB is downstream of the CXCL1-CXCR2 signaling pathway. Here, CXCR2 is linked to liver dysplastic nodule.