Mutations in LMNA associate with a wide range of human diseases collectively referred to as “laminopathies” encompassing not only DCM, but also muscular dystrophy, lipodystrophy, peripheral neuropathy, and Hutchinson Gilford Progeria (premature aging syndrome; Capell and Collins, 2006; Rankin and Ellard, 2006). Here, LMNA is linked to familial dilated cardiomyopathy.