LMNA and Emery-Dreifuss muscular dystrophy: A homozygous mutant LmnaH222P/H222P mouse model based on a human mutation associated with Emery-Dreifuss muscular dystrophy has been the basis for much of the molecular mechanistic studies of LMNA-DCM (Muchir et al., 2007; Muchir et al., 2009).