AGT and hypertensive disorder: CR was able to attenuate the angiotensin 2-induced hypertension in diabetic mice (Waldman et al., 2018), ameliorate angiotensin 2-induced cardiomyocyte hypertrophy, fibrosis, and apoptosis (Finckenberg et al., 2012) and to improve the lipid profile (Waldman et al., 2018).