ACE and chronic kidney disease: Since angiotensin-converting enzyme inhibitors are one of the standard treatments for patients with albuminuria (Agodoa et al., 2001; Jafar et al., 2001; Progression of Chronic Kidney Disease, 2003; Chu et al., 2021), we hypothesized that ACE inhibition would reduce hyperfiltration and renal inflammation leading to a reduction in the early progression of proteinuria in SSLepRmutant rats prior to puberty.