AGT and hypertensive disorder: Angiotensin II (AngII), one of the major metabolites of RAS, is elevated in obese subjects with renal disease and causes hypertension and stimulates renal inflammation (Suzuki et al., 2003; Schmieder et al., 2007; Yvan-Charvet and Quignard-Boulange, 2011; Kalupahana et al., 2012; Kalupahana and Moustaid-Moussa, 2012; Alique et al., 2014; Li et al., 2015).