The 119 UR targets correlated with Aβ pathology, tau pathology and Alzheimer disease pathway were categorized into 7 different classes based on their cellular function, of which protein modifying enzyme (PC00260, 45 targets) was the most enriched class, followed by transmembrane signal receptor (PC00197, 31 targets) and metabolite interconversion enzyme (PC00262, 20 targets) (Figure 4A). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.