MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease (AD) is the most common type of dementia characterized by extracellular amyloid-β (Aβ) plaques, intracellular aberrant hyperphosphorylated tau protein, neuronal synaptic dysfunction, and neuronal loss (Wallace and Dalton, 2011; Scheltens et al., 2016; Asaad and Lee, 2018).