In an experiment in which anti-CD20 antibodies depleted B cells in NOD mice, MDSC amplified, inhibited the function of CD4+ and CD8+T cells through cell-to-cell contact and released IL-10 and NO, ultimately inhibiting the development of type 1 diabetes in mice (Hu et al., 2012). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.