BDNF and epilepsy: Orally myricetin administration (100 or 200 mg/kg, 26 days, 30 min prior to each pentylenetetrazol injection) can reduce seizure rates in a mouse model of epilepsy induced by pentylenetetrazole likely through up-regulating the expression of Bcl-2, Bcl-xL, brain-derived neurotrophic factor (BDNF), glutamate decarboxylase 65 (GAD65), and γ-aminobutyric acid (GABAA), down-regulating the expression of caspase-3, Bad, and Bax, up-regulating the levels of GABA, and reducing glutamate contents and matrix metalloprotein-9 (MMP-9) activity in the hippocampus (Sun et al., 2019).