BRF1 and neoplasm: Similarly, the TATA box-binding protein human Maf1 and the oncogene Ras can promote the transcription of tRNAs by targeting RNA pol III, particularly the Brf1 subunit of TFIII B factor, thereby promoting tumor progression (Wang et al., 1997; Shen et al., 1998; Rollins et al., 2007; Johnson et al., 2008).