APP and Alzheimer disease: It is notable that purine metabolism was significantly altered in untreated 5xFAD females compared to WT females in our study, and that dysregulation of purine metabolism has previously been demonstrated in APP/PS1 (González-Domínguez et al., 2014; González-Domínguez et al., 2015) and 3xTgAD (Esteve et al., 2017; Zhao et al., 2021) mouse models of AD as well.