At high concentrations, many antidepressants and antipsychotics may affect lipid dynamics through inhibition of acid sphingomyelinase (Kornhuber et al., 2011) or direct manipulation of the lipid bilayer (Kapoor et al., 2019) resulting in phospholipidosis (Tummino et al., 2021) and toxicity. The gene discussed is SMPD1; the disease is lysosomal storage disease.