Inhibiting sEH is also beneficial by limiting diet-induced ER stress (Bettaieb et al., 2013), and decreasing diet-induced metabolic syndrome in obese rats (Iyer et al., 2012), renal injury in hypertensive obese rats (Imig et al., 2009), and endothelial disfunction in animal models (Zhang et al., 2011), among other biology. The gene discussed is EPHX2; the disease is metabolic syndrome.