In comparison with healthy controls, patients with major depression have higher concentrations of inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and C-reactive protein (CRP), while lower IL-10 concentration in blood (Euteneuer et al., 2017; Felger et al., 2020). The gene discussed is TNF; the disease is major depressive disorder.