Among 60 patients, TMP was found to act as a salvage agent in combination with chemotherapy and could increase the response rate, prolong the progression-free survival with manageable toxicity, and correlate with p-glycoprotein (P-gp) expression in relapsed or refractory non-Hodgkin’s lymphoma (NHL) (Yang et al., 2010). The gene discussed is ABCB1; the disease is non-Hodgkin lymphoma.