The antitumor efficacy of TMP was investigated in the human ccRCC cell line and found to inhibit ccRCC cell viability, proliferation, apoptosis, invasion, and migration by inhibiting the NKG2D-related signaling pathway to further suppress epithelial–mesenchymal transition (EMT) progression. This evidence concerns the gene KLRK1 and nonpapillary renal cell carcinoma.