Zou et al. (2018) synthesized a compound by replacing the trimethoxyphenyl group of piperlongumine 1 with a TMP moiety. In the colorectal cancer cell line HCT-116, this compound increased ROS levels, and inhibited proliferation, migration, invasion, and heteroadhesion to a greater extent than piperlongumine 1 through EMT induced by TGF-β1 and Wnt/β-catenin activation by inhibiting Akt and GSK-3β phosphorylation, in addition to suppressing tumor growth and lung metastasis in vivo to prolong the survival of tumor-bearing mice (Zou et al., 2018). The gene discussed is GSK3B; the disease is neoplasm.