As shown in Figure 11, our results demonstrate that the expressions of Th1 type cytokines IL-12p70 and Treg type cytokine IL-10 were significantly up-regulated after dextrose prolotherapy in IC/BPS patients when compared to before treatment, whereas no significant differences were found for the expressions of Th17 type cytokines IL-6 and IL-17F, Th2 type cytokine IL-13, and IL-27. This evidence concerns the gene IL6 and Bartsocas-Papas syndrome 1.