NFKB1 and neoplasm: Moreover, another study by Yuan et al. (Yuan et al., 2017) found that the synergistic inhibitory effect of the combination of Rg3 and paclitaxel in triple-negative breast cancer (TNBC) cells, including three cancer cell lines MDA-MB-231, MDA-MB-453, and BT-549, resulted from regulation of apoptotic proteins and genes and inactivation of NF-κB. Additionally, reduction of tumor volumes and weights in the nude mice implanted with TNBC cells in vivo after co-treatment of Rg3 and paclitaxel was observed.