EGFR and neoplasm: Epidermal growth factor receptor (EGFR), known as a key factor in the development of tumor, can bind with a ligand, which leads to autophosphorylation of the receptor, activate downstream signal transduction and activity, involving Ras/MAPK, PI3K/AKT, STAT, and Src family kinases, and promote proliferation, survival, invasion, and migration of tumor cells (Wieduwilt and Moasser, 2008).