Rg3 could sensitize hypoxia human NSCLC cells to DDP by inhibiting the NF-κB pathway thereby retaining the progress of EMT and stemness evidenced as reduced expressions of E-cadherin, N-cadherin, sex determining region Y-box 2 (SOX2), NANOG, OCT4, and CD44. Here, SOX2 is linked to non-small cell lung carcinoma.