CASC2 and cervical carcinoma: For example, Feng et al. (Feng et al., 2017) found that inhibition of the CASC2/PTEN/Akt pathway sensitized DDP-resistant cervical cancer cells to DDP since overexpression of CASC2 reduced IC50 values in HeLa/DDP and CaSki/DDP cells, while CASC2 knockdown promoted IC50 values.