BCL2L1 and cancer: Chen et al., 2019a). Similarly, the developed polyethyleneglycol of long-circulating homoharringtonine liposomes has been shown to suppress CD138-CD34− (Figure 11) multiple myeloma cancer stem cells via autophagy and apoptosis in vitro and in vivo in a xenograft mouse model (M. Li et al., 2017). Recent studies have revealed the antitumor effect of homoharringtonine against rhabdoid tumors both in vitro and in patient-derived xenograft tumors, which may be due to the low expression of BCL2L1 in cancer cell lines (Howard et al., 2020).