APP and early-onset autosomal dominant Alzheimer disease: 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), an active compound was purified from the roots of Averrhoa carambola L. Previous studies have reported that DMDD improves cognitive impairment by protected against neuronal apoptosis in APP/PS1 Alzheimer’s disease mice (Wei et al., 2018).