PSEN1 and familial Alzheimer disease: In addition to improve memory consolidation processes in rats and mice (Bollen et al., 2013), 7,8-DHF activates TRKB signaling to rescue amyloid-beta (Aβ)-induced neurotoxicity and synaptic dysfunction in transgenic mice expressing five familial AD-linked amyloid beta precursor protein (APP) and presenilin 1 (PS1) mutations [5 × familial Alzheimer’s disease (FAD)] (Devi and Ohno, 2012; Zhang et al., 2014).