Studies have shown that apigenin (4′,5,7-trihydroxyflavone) ameliorates learning and memory impairment through relieving Aβ burden, suppressing amyloidogenic process, and restoring ERK/CREB/BDNF pathway in APP and PS1 double transgenic AD mice (Zhao et al., 2013). Here, PSEN1 is linked to Alzheimer disease.