PSEN1 and Alzheimer disease: Quercetin (3,3′,4′,5,7-pentahydroxyflavone) decreases β-amyloidosis and tauopathy and protects the cognitive function in APP, PS1, and Tau triple-transgenic AD mouse model (3 × Tg-AD mice) (Sabogal-Guáqueta et al., 2015; Pérez-Corredor et al., 2019).