PVALB and amyotrophic lateral sclerosis: Recent work has demonstrated a reduction in parvalbumin interneurons, the major class of interneuron in the motor cortex (Estebanez et al., 2017), in a TDP-43Q331K model of ALS-FTD and C9ORF72RE ALS patient post-mortem suggesting the loss of inhibition may well also come from a selective vulnerability of this neuron class (Lin et al., 2021).