Hippocampal synaptic plasticity was evidenced in murine models: UBQLN2P497H(Gorrie et al., 2014); SOD1G93A (Spalloni et al., 2011); TDP-43 transgenic mice (Koza et al., 2019), TDP-43 conditional knockout mice (Wu et al., 2019); non-TDP-43 FTD models (progranulin knock out mice (Petkau et al., 2012) and MAPT knockout (Ahmed et al., 2014; Biundo et al., 2018). The gene discussed is GRN; the disease is frontotemporal dementia.