Importantly, the interneuronal hypothesis also extends to non-TDP-43 FTD forms where interneuronal pathology is observed in murine FTD models (Lui et al., 2016) and noting that interneurons control cortical network synchronicity, may underlie altered EEG activity in FTD patients (Lindau et al., 2003; Nishida et al., 2011). Here, TARDBP is linked to frontotemporal dementia.