Others, however, have shown tasquinimod to block the trafficking of myeloid derived suppressive cells (which inhibit the anti-tumor activity of CD8 and CD4 cells) (Raymond et al., 2014), change the polarization of tumor-associated macrophages into M1 phenotype (Olsson et al., 2015), and improve efficacy of PD-L1 blockade (Shen et al., 2015; Nakhle et al., 2016). The gene discussed is CD4; the disease is neoplasm.