NPTN and male infertility: The loss of neuroplastin affects cellular functions as Ca2+ homeostasis, long-term-potentiation, synapse formation, and more (Bhattacharya et al., 2017; Korthals et al., 2017) resulting ultimately in pronounced deficits including male infertility, depression-like behavior, and learning and memory deficits in Nptn mutants (Bhattacharya et al., 2017).